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CFM 4

CAS No. 331458-02-7

CFM 4( —— )

Catalog No. M33838 CAS No. 331458-02-7

CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 55 Get Quote
5MG 76 Get Quote
10MG 122 Get Quote
25MG 242 Get Quote
50MG 362 Get Quote
100MG 518 Get Quote
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Biological Information

  • Product Name
    CFM 4
  • Note
    Research use only, not for human use.
  • Brief Description
    CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.
  • Description
    CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    APC | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    331458-02-7
  • Formula Weight
    405.9
  • Molecular Formula
    C22H16ClN3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (61.59 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1C2(C=3C(N1CC4=C(Cl)C=CC=C4)=CC=CC3)SC(=NN2)C5=CC=CC=C5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017.?
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